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Iloperidone for Uncontrolled Hypertension

High blood pressure (hypertension) occurs when the force of blood against artery walls is consistently too high. Over time, this can increase the risk of serious health conditions such as heart disease, stroke, and kidney problems. While many medications are available, some individuals continue to have difficulty controlling their blood pressure even with ongoing treatment.

Adults 18–65 with a history of high blood pressure that remains elevated despite treatment may qualify for a study evaluating an investigational medication designed to help lower blood pressure.

Age Range: 18 to 65

Gender: Male and Female

Location: Rochester, New York

About the Study

This research study is evaluating an investigational use of iloperidone, a medication currently approved for certain psychiatric conditions, to determine whether it may also help lower blood pressure. Researchers will assess how effective the study drug is compared to placebo and evaluate its safety and tolerability in adults with uncontrolled hypertension.

The study includes several phases: an initial screening period, a short open-label titration phase with oral medication, and a randomized double-blind treatment phase. In the treatment phase, participants will receive a single dose of either a long-acting injectable form of iloperidone or a placebo for comparison. Participants will continue their regular blood pressure medications throughout the study.

Qualifications

You may be able to join if you:

Are 18 to 65 years old.

Have a history of hypertension and are currently taking blood pressure medication but still have elevated readings.

Have been on stable antihypertensive treatment for at least 8 weeks.

Are able to comply with study visits, monitoring, and procedures.

Do not have severe or uncontrolled cardiovascular conditions or very high blood pressure requiring urgent treatment.

Do not have significant kidney disease or other serious medical conditions that may affect participation.

Do not have certain psychiatric or neurological conditions such as schizophrenia or seizure disorders.

Are not pregnant or breastfeeding.

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Volunteer for this Study

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